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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K1
All Species:
45.15
Human Site:
S90
Identified Species:
76.41
UniProt:
Q02750
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02750
NP_002746.1
393
43439
S90
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
S90
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
Rhesus Macaque
Macaca mulatta
XP_001110225
393
43444
S90
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P31938
393
43456
S90
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
Rat
Rattus norvegicus
Q01986
393
43447
S90
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511248
391
43070
R111
R
P
P
S
L
M
P
R
L
W
L
I
H
L
E
Chicken
Gallus gallus
Q90891
398
44059
S92
T
K
V
Q
H
K
P
S
G
L
I
M
A
R
K
Frog
Xenopus laevis
Q05116
395
43724
T90
F
K
V
S
H
K
P
T
S
L
I
M
A
R
K
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
S102
D
K
M
R
H
V
P
S
G
V
I
M
A
V
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
T109
M
K
V
R
H
T
H
T
H
L
I
M
A
R
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
T95
N
K
C
V
H
R
K
T
G
V
I
M
A
R
K
Sea Urchin
Strong. purpuratus
XP_781505
412
45737
S109
T
K
V
K
H
K
M
S
G
M
V
M
A
R
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
T92
Q
L
V
Q
H
K
W
T
G
Q
F
F
A
L
K
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
T382
S
K
V
L
H
K
P
T
N
V
I
M
A
T
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
98.9
99.2
N.A.
73
81.6
91.9
33.3
N.A.
62.3
N.A.
52.4
64.8
Protein Similarity:
100
99.2
100
N.A.
N.A.
99.4
99.7
N.A.
77.8
88.9
96.1
51.4
N.A.
77.7
N.A.
69.2
75.7
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
13.3
80
80
53.3
N.A.
53.3
N.A.
46.6
73.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
33.3
86.6
93.3
73.3
N.A.
66.6
N.A.
73.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.3
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.4
33.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
93
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% E
% Phe:
43
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
72
0
0
0
0
0
0
% G
% His:
0
0
0
0
93
0
8
0
8
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
43
8
0
0
0
% I
% Lys:
0
86
0
8
0
72
8
0
0
0
0
0
0
0
93
% K
% Leu:
0
8
0
8
8
0
0
0
8
58
8
0
0
15
0
% L
% Met:
8
0
8
0
0
8
8
0
0
8
0
86
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
0
8
8
0
0
0
72
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
15
0
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
8
0
0
15
0
8
0
8
0
0
0
0
0
72
0
% R
% Ser:
8
0
0
50
0
0
0
58
8
0
0
0
0
0
0
% S
% Thr:
15
0
0
0
0
8
0
36
0
0
0
0
0
8
0
% T
% Val:
0
0
79
8
0
8
0
0
0
22
43
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _